Diarrhea occurs 6–8 h after diphenylmethane cathartics are administered, and can be severe after large doses (Boothe, 2001). Phenolphthalein is used as a laxative to treat incomplete and infrequent bowel movement. It also serves as a component of universal indicator, together with methyl red, bromothymol blue, and thymol blue. After reviewing the benefits and risks associated with the use of phenolphthalein-containing laxatives, Health Canada concluded that there is a risk that phenolphthalein may cause cancer in humans; therefore authority to sell and distribute these products was revoked. Phenolphthalein inhibited human 20α-HSD with IC50 of 330 nM (Higaki et al., 2003). I agree to the Titanium complexes containing methylsalicylate, phenolphthalein,522 furoic acid, isotan and picolinic acid ligands have been described.523 Keto–alkoxide complexes such as TiCl3(O2C6H7)524 and various maltolato derivatives525,526 have been prepared and characterized. While toxic to consume on its own, it’s available in tiny doses in many household products like mouthwash and spray cleaners. This has raised suspicions over the use of phenolphthalein by humans. Phenol evaporates more slowly than water, and a moderate amount can form a solution with water. Further to the actions taken in the USA and France to withdraw laxative products containing phenolphthalein, the following measures have been taken [33]. Smith, D.W. Stephan, in Comprehensive Coordination Chemistry II, 2003. Table 28.5 lists common types of irritant laxative. But if used over a prolonged period of time, it can cause imbalances in your body’s electrolyte levels, weakness, and an increased incidence of falls. Catharsis is accompanied by reduced hydration and electrolyte loss. It is used in pressed-wood products, such as particleboard, plywood, and fiberboard; glues and adhesives; permanent-press fabrics; paper product coatings; and certain insulation materials. This Journal. Unfortunately, there are insufficient data about carcinogenicity of this compound in humans, although this compound is probably carcinogenic in human considering its carcinogenicity in animals. Positive: Immediate color change to pink or red after addition of carbonate solution (compare results with a set of color standards and record intensity of color (− to 5+). Pink discoloration of alkaline urine can be used to confirm phenolphthalein ingestion. Phenolphthalein exerts laxative effects by stimulating the intestinal mucosa and constricting smooth muscles. Phenolphthalein is also prescribed for the treatment of chronic atonic or spastic constipation and of constipation associated with rectal disorders; management of irritable bowel syndrome. Ricinoleic acid is the most potent of these compounds, and initiates rapid and complete colonic emptying. It is available in the form of an oral solution, oral capsule, oral tablet, wafer and chewing gum. Bisacodyl, for example, stimulates nitric oxide–mediated epithelial cell secretion and myenteric neuronal depolarization.12 Diarrhea results from the combined effect of increased mucosal secretion and colonic propulsion. Common anthraquinone-type cathartics are derived from plants: cascara sagrada from Rhamnus spp., senna from Senna spp., and aloin from Aloe spp. Phenol, chemically known as carbolic acid, is a white, volatile crystal solid. Danthron (1,8-dihydroxyanthroquinone) is synthetic, but is considered the prototype for the anthraquinone laxative group. There is some absorption of anthraquinone glycosides, and delayed transit through the small intestine decreases effectiveness. Licorice component glycyrrhetinic acid has been reported to inhibit many HSDs including 3β-HSD2, 11β-HSD1, 11β-HSD2, and 17β-HSD3 (Ma, Lian, Dong, & Ge, 2011; Monder et al., 1989; Ye, Su, & Ge, 2011). We use cookies to help provide and enhance our service and tailor content and ads. Sterilize by filtration through 0.22 µm pore size membrane filter and store at 5°C. With chronic use of these laxatives, the myenteric plexus will degenerate causing a loss in intestinal motility. Anthraquinones produce catharsis after 6–12 h in small animals and 12–36 h in large animals (Boothe, 2001). Remember Me Phenolphthalein, ACS Safety Data Sheet according to Federal Register / Vol. Phenol is an aromatic compound. Potentially toxic to reproduction: comes from a harmonised C&L classifying the substance as suspected toxic to reproduction Repr. Phenolphthalein Indicator Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com TSCA (Toxic Substances Control Act): All ingredients are listed. Phenolphthalein was once widely used as a laxative for self-treatment, often camouflaged in chocolate and thus liable to abuse or accidental use; it is now obsolete. Anthraquinones are hydrolyzed by bacteria in the large intestine to emodins, which stimulate the myenteric plexus. Discussion: Phenolphthalein is the active ingredient in several over-the-counter laxative preparations and has only rarely been reported to … phenolphthalein. 0 0 Firefighters should wear full fire fighting turn-out gear and respiratory protection (SCBA). Other monoanionic bidentate oxygen-based ligand complexes include TiCl2((OPR2)2N)2 (R = Cl, Ph,528 OPh,529), TiCl2(OPPh2CH2CH(Me)O)2, TiCl2(OPPh2 CH2CH(Ph)O)2,530 TiCl2(OC20H12P(O)Ph2)2,531 and Ti(OPri)3(OP(OMe)2CH(OPri)O)532. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780123864543011362, URL: https://www.sciencedirect.com/science/article/pii/B9780444537171009604, URL: https://www.sciencedirect.com/science/article/pii/B9780128000953000134, URL: https://www.sciencedirect.com/science/article/pii/B9780128146927000024, URL: https://www.sciencedirect.com/science/article/pii/B9781416036616000109, URL: https://www.sciencedirect.com/science/article/pii/B0080437486030280, URL: https://www.sciencedirect.com/science/article/pii/B978141603661600050X, URL: https://www.sciencedirect.com/science/article/pii/B9780128114100000210, URL: https://www.sciencedirect.com/science/article/pii/B9780123859266000284, Encyclopedia of Toxicology (Third Edition), Meyler's Side Effects of Drugs (Sixteenth Edition), Ma, Lian, Dong, & Ge, 2011; Monder et al., 1989; Ye, Su, & Ge, 2011, Shimada, Ohtaguro, Miura, & Imamura, 2007, Identification of Nontuberculous Mycobacterium, Hartmans and de Bont, 1992; Kent and Kubica, 1985; Smida et al., 1988; Rogall et al., 1990; Stahl and Urbance, 1990; Wayne and Diaz, 1985; Stackebrandt et al., 1987; Pitulle et al., 1992; World Health Organization, 1998.

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